Peripheral PDLIM5 expression in bipolar disorder and the effect of olanzapine administration.

ABSTRACT:

Background

One of the genes suggested to play an important role in the pathophysiology of bipolar disorder (BPD) is PDLIM5, which encodes LIM domain protein. Our main objective was to examine the effect of olanzapine treatment on PDLIM5 mRNA expression in the peripheral blood leukocytes of BPD patients.

Methods

We measured the expression of PDLIM5 mRNA from 16 patients with BPD Type I after 0, 4, and 8 weeks of treatment with olanzapine using quantitative real-time PCR. The Young Mania Rating Scale was used to evaluate the severity of manic symptoms in BPD patients. We also compared PDLIM5 mRNA expression in treatment-naïve BPD patients with that in healthy control subjects.

Results

No significant difference was found in PDLIM5 mRNA expression between patients before

SUBMITTER: Zain MA 

PROVIDER: S-EPMC3502145 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature