Dietary glycemic load and cancer recurrence and survival in patients with stage III colon cancer: findings from CALGB 89803.

ABSTRACT:

Background

The influence of glycemic load and related measures on survival among colon cancer patients remains largely unknown.

Methods

We conducted a prospective, observational study of 1011 stage III colon cancer patients reporting dietary intake during and 6 months after participation in an adjuvant chemotherapy trial. We examined the influence of glycemic load, glycemic index, fructose, and carbohydrate intakes on cancer recurrence and mortality using Cox proportional hazards regression; all tests of statistical significance were two-sided.

Results

Stage III colon cancer patients in the highest quintile of dietary glycemic load experienced an adjusted hazard ratio (HR) for disease-free survival of 1.79 (95% confidence interval [CI] = 1.29 to 2.48), compared with t

SUBMITTER: Meyerhardt JA 

PROVIDER: S-EPMC3502194 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature