N-methylpurine DNA glycosylase and OGG1 DNA repair activities: opposite associations with lung cancer risk.

ABSTRACT: Only a minority of smokers develop lung cancer, possibly due to genetic predisposition, including DNA repair deficiencies. To examine whether inter-individual variations in DNA repair activity of N-methylpurine DNA glycosylase (MPG) are associated with lung cancer, we conducted a blinded, population-based, case-control study with 100 lung cancer case patients and 100 matched control subjects and analyzed the data with conditional logistic regression. All statistical tests were two-sided. MPG enzyme activity in peripheral blood mononuclear cells from case patients was higher than in control subjects, results opposite that of 8-oxoguanine DNA glycosylase (OGG1) DNA repair enzyme activity. For lung cancer associated with one standard deviation increase in MPG activity, the adjusted odds ratio

SUBMITTER: Leitner-Dagan Y 

PROVIDER: S-EPMC3502197 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature