Substrate-specific gene expression in Batrachochytrium dendrobatidis, the chytrid pathogen of amphibians.

ABSTRACT: Determining the mechanisms of host-pathogen interaction is critical for understanding and mitigating infectious disease. Mechanisms of fungal pathogenicity are of particular interest given the recent outbreaks of fungal diseases in wildlife populations. Our study focuses on Batrachochytrium dendrobatidis (Bd), the chytrid pathogen responsible for amphibian declines around the world. Previous studies have hypothesized a role for several specific families of secreted proteases as pathogenicity factors in Bd, but the expression of these genes has only been evaluated in laboratory growth conditions. Here we conduct a genome-wide study of Bd gene expression under two different nutrient conditions. We compare Bd gene expression profiles in standard laboratory growth media and in pulverized host

SUBMITTER: Rosenblum EB 

PROVIDER: S-EPMC3502224 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature