Phylogeographic characterization of tick-borne encephalitis virus from patients, rodents and ticks in Slovenia.

ABSTRACT: Tick-borne encephalitis virus (TBEV) is the most important arboviral agent causing infections of the central nervous system in central Europe. Previous studies have shown that TBEV exhibits pronounced genetic variability, which is often correlated to the geographical origin of TBEV. Genetic variability of TBEV has previously been studied predominantly in rodents and ticks, while information about the variability in patients is scarce. In order to understand the molecular relationships of TBEV between natural hosts, vectors and humans, as well as correlation between phylogenetic and geographical clustering, sequences of TBEV E and NS5 protein genes, were obtained by direct sequencing of RT-PCR products from TBE-confirmed patients as well as from rodents and ticks collected from TBE-endemic

SUBMITTER: Fajs L 

PROVIDER: S-EPMC3502456 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature