A novel multiplex-protein array for serum diagnostics of colon cancer: a case-control study.

ABSTRACT:

Background

More than 1.2 million new cases of colorectal cancer are reported each year worldwide. Despite actual screening programs, about 50% of the patients are diagnosed at advanced tumor stages presenting poor prognosis. Innovative screening tools could aid the detection at early stages and allow curative treatment interventions.

Methods

A nine target multiplex serum protein biochip was generated and evaluated using a training- and validation-set of 317 highly standardized, liquid nitrogen preserved serum samples comprising controls, adenomas, and colon cancers.

Results

Serum levels of CEA, IL-8, VEGF, S100A11, MCSF, C3adesArg, CD26, and CRP showed significant differences between cases and controls. The largest areas under the receiver operating characteristics cu

SUBMITTER: Bunger S 

PROVIDER: S-EPMC3502594 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature