Identification of a novel set of genes reflecting different in vivo invasive patterns of human GBM cells.

ABSTRACT:

Background

Most patients affected by Glioblastoma multiforme (GBM, grade IV glioma) experience a recurrence of the disease because of the spreading of tumor cells beyond surgical boundaries. Unveiling mechanisms causing this process is a logic goal to impair the killing capacity of GBM cells by molecular targeting.We noticed that our long-term GBM cultures, established from different patients, may display two categories/types of growth behavior in an orthotopic xenograft model: expansion of the tumor mass and formation of tumor branches/nodules (nodular like, NL-type) or highly diffuse single tumor cell infiltration (HD-type).

Methods

We determined by DNA microarrays the gene expression profiles of three NL-type and three HD-type long-term GBM cultures. Subsequently, individ

SUBMITTER: Monticone M 

PROVIDER: S-EPMC3502598 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature