Correlates of protective cellular immunity revealed by analysis of population-level immune escape pathways in HIV-1.

ABSTRACT: HLA class I-associated polymorphisms identified at the population level mark viral sites under immune pressure by individual HLA alleles. As such, analysis of their distribution, frequency, location, statistical strength, sequence conservation, and other properties offers a unique perspective from which to identify correlates of protective cellular immunity. We analyzed HLA-associated HIV-1 subtype B polymorphisms in 1,888 treatment-naïve, chronically infected individuals using phylogenetically informed methods and identified characteristics of HLA-associated immune pressures that differentiate protective and nonprotective alleles. Over 2,100 HLA-associated HIV-1 polymorphisms were identified, approximately one-third of which occurred inside or within 3 residues of an optimally defined cyt

SUBMITTER: Carlson JM 

PROVIDER: S-EPMC3503140 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature