Antioxidant and anti-inflammatory role of paraoxonase 1: implication in arteriosclerosis diseases.

ABSTRACT: Paraoxonase 1 (PON1) is a hydrolytic enzyme with wide range of substrates, and capability to protect against lipid oxidation. Despite of the large number of compounds that can be hydrolyzed by paraoxonase, the biologically relevant substrates are still not clearly determined. There is a massive in vitro and in vivo data to demonstrate the beneficial effects of PON1 in several atherosclerosis-related processes. The enzyme is primarily expressed in liver; however, it is also localized in other tissues. PON1 attracted significant interest as a protein that is responsible for the most of antioxidant properties of high-density lipoprotein (HDL). Several bioactive molecules such as dietary polyphenols, aspirin and its hydrolysis product salicylate, are known to stimulate PON1 transcription activ

SUBMITTER: Litvinov D 

PROVIDER: S-EPMC3503369 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature