Genome-wide ancestry association testing identifies a common European variant on 6q14.1 as a risk factor for asthma in African American subjects.

ABSTRACT:

Background

Genetic variants that contribute to asthma susceptibility might be present at varying frequencies in different populations, which is an important consideration and advantage for performing genetic association studies in admixed populations.

Objective

We sought to identify asthma-associated loci in African American subjects.

Methods

We compared local African and European ancestry estimated from dense single nucleotide polymorphism genotype data in African American adults with asthma and nonasthmatic control subjects. Allelic tests of association were performed within the candidate regions identified, correcting for local European admixture.

Results

We identified a significant ancestry association peak on chromosome 6q. Allelic tests for association wi

SUBMITTER: Torgerson DG 

PROVIDER: S-EPMC3503456 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature