Transcriptomic and metabolomic profiling of chicken adipose tissue in response to insulin neutralization and fasting.

ABSTRACT:

Background

Domestic broiler chickens rapidly accumulate adipose tissue due to intensive genetic selection for rapid growth and are naturally hyperglycemic and insulin resistant, making them an attractive addition to the suite of rodent models used for studies of obesity and type 2 diabetes in humans. Furthermore, chicken adipose tissue is considered as poorly sensitive to insulin and lipolysis is under glucagon control. Excessive fat accumulation is also an economic and environmental concern for the broiler industry due to the loss of feed efficiency and excessive nitrogen wasting, as well as a negative trait for consumers who are increasingly conscious of dietary fat intake. Understanding the control of avian adipose tissue metabolism would both enhance the utility of chicken as a

SUBMITTER: Ji B 

PROVIDER: S-EPMC3503602 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature