DICER1 RNase IIIb domain mutations are infrequent in testicular germ cell tumours.

ABSTRACT:

Background

Testicular Germ Cell Tumours (TGCT) are the most frequently occurring malignancy in males from 15-45 years of age. They are derived from germ cells unable to undergo physiological maturation, although the genetic basis for this is poorly understood. A recent report showed that mutations in the RNase IIIb domain of DICER1, a micro-RNA (miRNA) processing enzyme, are common in non-epithelial ovarian cancers. DICER1 mutations were found in 60% of Sertoli-Leydig cell tumours, clustering in four codons encoding metal-binding sites. Additional analysis of 14 TGCT DNA samples identified one case that also contained a mutation at one of these sites.

Findings

A number of previous studies have shown that DICER1 mutations are found in <1% of most cancers. To provide a more ac

SUBMITTER: de Boer CM 

PROVIDER: S-EPMC3503615 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature