Altered gene expression pattern in peripheral blood mononuclear cells in patients with acute myocardial infarction.

ABSTRACT:

Background

Despite a substantial progress in diagnosis and therapy, acute myocardial infarction (MI) is a major cause of mortality in the general population. A novel insight into the pathophysiology of myocardial infarction obtained by studying gene expression should help to discover novel biomarkers of MI and to suggest novel strategies of therapy. The aim of our study was to establish gene expression patterns in leukocytes from acute myocardial infarction patients.

Methods and results

Twenty-eight patients with ST-segment elevation myocardial infarction (STEMI) were included. The blood was collected on the 1(st) day of myocardial infarction, after 4-6 days, and after 6 months. Control group comprised 14 patients with stable coronary artery disease, without history of myoca

SUBMITTER: Kiliszek M 

PROVIDER: S-EPMC3503717 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature