CD133 expression predicts lung metastasis and poor prognosis in osteosarcoma patients: A clinical and experimental study.

ABSTRACT: Identifying prognostic factors for osteosarcoma (OS) aids in the selection of patients who require more aggressive management. CD133 has been found to be a prognostic factor of certain tumor types. However, the association between CD133 expression and the prognosis of OS remains unknown. In this study, we analyzed the association of CD133 expression in OS with clinical factors and overall survival, and further investigated its potential role in metastasis in vitro. We found CD133 expression in 65.7% (46/70) of OS samples using immunohistochemistry, and it was positively correlated with lung metastasis analyzed by Chi-square test (P=0.002) and shorter overall survival time using the Kaplan-Meier method compared by log-rank test (P=0.000). Multivariate analysis showed that CD133 expression w

SUBMITTER: He A 

PROVIDER: S-EPMC3503795 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature