Antibodies against conserved amidated neuropeptide epitopes enrich the comparative neurobiology toolbox.

ABSTRACT:

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Background

Neuronal antibodies that show immunoreactivity across a broad range of species are important tools for comparative neuroanatomy. Nonetheless, the current antibody repertoire for non-model invertebrates is limited. Currently, only antibodies against the neuropeptide RFamide and the monoamine transmitter serotonin are extensively used. These antibodies label respective neuron-populations and their axons and dendrites in a large number of species across various animal phyla.

Results

Several other neuropeptides also have a broad phyletic distribution among invertebrates, including DLamides, FVamides, FLamides, GWamides and RYamides. These neuropeptides show strong conservation of the two carboxy-terminal amino acids and are α-amidated at their C-ter

SUBMITTER: Conzelmann M 

PROVIDER: S-EPMC3503879 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature