MicroRNAs from the same precursor have different targeting properties.

ABSTRACT:

Unlabelled

Background

The processing of a microRNA results in an intermediate duplex of two potential mature products that derive from the two arms (5' and 3') of the precursor hairpin. It is often suggested that one of the sequences is degraded and the other is incorporated into the RNA-induced silencing complex. However, both precursor arms may give rise to functional levels of mature microRNA and the dominant product may change from species to species, from tissue to tissue, or between developmental stages. Therefore, both arms of the precursor have the potential to produce functional mature microRNAs.

Results

We have investigated the relationship between predicted mRNA targets of mature sequences derived from the 5' and 3' arms of the same pre-microRNAs. Using si

SUBMITTER: Marco A 

PROVIDER: S-EPMC3503882 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature