Human neural progenitor cell engraftment increases neurogenesis and microglial recruitment in the brain of rats with stroke.

ABSTRACT:

Main objectives

Stem cell transplantation is to date one of the most promising therapies for chronic ischemic stroke. The human conditionally immortalised neural stem cell line, CTX0E03, has demonstrable efficacy in a rodent model of stroke and is currently in clinical trials. Nonetheless, the mechanisms by which it promotes brain repair are not fully characterised. This study investigated the cellular events occurring after CTX0E03 transplantation in the brains of rats that underwent ischemic stroke.

Methods

We focused on the endogenous proliferative activity of the host brain in response to cell transplantation and determined the identity of the proliferating cells using markers for young neurons (doublecortin, Dcx) and microglia (CD11b). So as to determine the chronology

SUBMITTER: Hassani Z 

PROVIDER: S-EPMC3503964 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature