Exploring gene expression signatures for predicting disease free survival after resection of colorectal cancer liver metastases.

ABSTRACT:

Background and objectives

This study was designed to identify and validate gene signatures that can predict disease free survival (DFS) in patients undergoing a radical resection for their colorectal liver metastases (CRLM).

Methods

Tumor gene expression profiles were collected from 119 patients undergoing surgery for their CRLM in the Paul Brousse Hospital (France) and the University Medical Center Utrecht (The Netherlands). Patients were divided into high and low risk groups. A randomly selected training set was used to find predictive gene signatures. The ability of these gene signatures to predict DFS was tested in an independent validation set comprising the remaining patients. Furthermore, 5 known clinical risk scores were tested in our complete patient cohort.

Resu

SUBMITTER: Snoeren N 

PROVIDER: S-EPMC3504021 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature