Empirical distributions of F(ST) from large-scale human polymorphism data.

ABSTRACT: Studies of the apportionment of human genetic variation have long established that most human variation is within population groups and that the additional variation between population groups is small but greatest when comparing different continental populations. These studies often used Wright's F(ST) that apportions the standardized variance in allele frequencies within and between population groups. Because local adaptations increase population differentiation, high-F(ST) may be found at closely linked loci under selection and used to identify genes undergoing directional or heterotic selection. We re-examined these processes using HapMap data. We analyzed 3 million SNPs on 602 samples from eight worldwide populations and a consensus subset of 1 million SNPs found in all populations. We

SUBMITTER: Elhaik E 

PROVIDER: S-EPMC3504095 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature