Liver regeneration signature in hepatitis B virus (HBV)-associated acute liver failure identified by gene expression profiling.

ABSTRACT:

Introduction

The liver has inherent regenerative capacity via mitotic division of mature hepatocytes or, when the hepatic loss is massive or hepatocyte proliferation is impaired, through activation of hepatic stem/progenitor cells (HSPC). The dramatic clinical course of acute liver failure (ALF) has posed major limitations to investigating the molecular mechanisms of liver regeneration and the role of HSPC in this setting. We investigated the molecular mechanisms of liver regeneration in 4 patients who underwent liver transplantation for hepatitis B virus (HBV)-associated ALF.

Methods and findings

Gene expression profiling of 17 liver specimens from the 4 ALF cases and individual specimens from 10 liver donors documented a distinct gene signature for ALF. However, unsupervis

SUBMITTER: Nissim O 

PROVIDER: S-EPMC3504149 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature