Associations between the pubertal timing-related variant in LIN28B and BMI vary across the life course.

ABSTRACT:

Context

The common C allele of rs314276 in LIN28B has been robustly associated with earlier age at menarche in girls and associated with earlier timing of other pubertal traits in both sexes.

Objective

Our objective was to explore the associations between rs314276, as a marker of earlier pubertal timing, and body mass index (BMI), weight, and height across the life course.

Methods

The rs314276 in LIN28B was genotyped in 1242 men and 1209 women born in 1946 and participating in the Medical Research Council National Survey of Health and Development. Birth weight was recorded, and height and weight were measured or self-reported repeatedly at 11 time points between ages 2 and 53 yr. Polynomial mixed models were used to test whether additive genetic associations with sd s

SUBMITTER: Ong KK 

PROVIDER: S-EPMC3504301 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature