Ontology highlight
ABSTRACT:
SUBMITTER: Bolam JP
PROVIDER: S-EPMC3504389 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Bolam J Paul JP Pissadaki Eleftheria K EK
Movement disorders : official journal of the Movement Disorder Society 20120924 12
Although genes, protein aggregates, environmental toxins, and other factors associated with Parkinson's disease (PD) are widely distributed in the nervous system and affect many classes of neurons, a consistent feature of PD is the exceptional and selective vulnerability of dopamine (DA) neurons of the SNc. What is it about these neurons, among all other neurons in the brain, that makes them so susceptible in PD? We hypothesize that a major contributory factor is the unique cellular architecture ...[more]