Longitudinal analysis of retinal hemangioblastomatosis and visual function in ocular von Hippel-Lindau disease.

ABSTRACT:

Objective

Characterization of the structural and functional progression of ocular von Hippel-Lindau (VHL) disease and analysis of patient factors influencing disease progression.

Design

Retrospective analysis of a case series from a longitudinal, observational study.

Participants

Two hundred forty-nine participants with clinically defined systemic VHL disease and more than 2 years of ophthalmic follow-up.

Methods

Standardized scoring of ocular phenotype and systemic characteristics was performed at each study visit and was analyzed longitudinally to determine progression of ocular VHL disease.

Main outcome measures

Measures evaluated include: visual acuity, features of ocular VHL disease (presence, location, number, and extent of retinal capillary hemang

SUBMITTER: Toy BC 

PROVIDER: S-EPMC3504630 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature