A structure-based model of RIG-I activation.

ABSTRACT: A series of high-resolution crystal structures of RIG-I and RIG-I:dsRNA cocrystals has recently been reported. Comparison of these structures provides considerable insight into how this innate immune pattern recognition receptor is activated upon detecting and binding a certain class of viral RNAs.

SUBMITTER: Kolakofsky D 

PROVIDER: S-EPMC3504664 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature