Paracrine and transpresentation functions of IL-15 are mediated by diverse splice versions of IL-15Rα in human monocytes and dendritic cells.

ABSTRACT:

Background

IL-15 can either be transpresented by IL-15Rα or be secreted.

Results

New N- and C-terminal splice versions of human IL-15Rα determine whether IL-15 is secreted or stays bound to the cell membrane.

Conclusion

IL-15Rα isoforms determine the mode of action of IL-15.

Significance

IL-15Rα isoforms may modify immune response outcomes in humans. Species-specific differences of post-translational modifications suggested the existence of human IL-15Rα isoforms. We identified eight new isoforms that are predicted to modify the intracellular C termini of IL-15Rα, and another N-terminal exon "Ex2A" that was consistently present in all but one of the C-terminal isoforms. Ex2A encodes a 49-amino acid domain that allowed the transfer of IL-15/IL-15Rα complex to th

SUBMITTER: Muller JR 

PROVIDER: S-EPMC3504748 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature