Notch3 and Mef2c proteins are mutually antagonistic via Mkp1 protein and miR-1/206 microRNAs in differentiating myoblasts.

ABSTRACT:

Background

Notch3 is expressed in myogenic precursors, but its function is not well known.

Results

Notch3 represses the activity of Mef2c and is in turn inhibited by the microRNAs-1 and -206.

Conclusion

Notch3 serves as a regulator for preventing premature myogenic differentiation.

Significance

Understanding how precocious differentiation is prevented is critical for designing therapy for skeletal muscle regeneration. The Notch signaling pathway is a well known regulator of skeletal muscle stem cells known as satellite cells. Loss of Notch1 signaling leads to spontaneous myogenic differentiation. Notch1, normally expressed in satellite cells, is targeted for proteasomal degradation by Numb during differentiation. A homolog of Notch1, Notch3, is also expressed i

SUBMITTER: Gagan J 

PROVIDER: S-EPMC3504751 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature