Regulation of Na(+)/K(+)-ATPase by nuclear respiratory factor 1: implication in the tight coupling of neuronal activity, energy generation, and energy consumption.

ABSTRACT:

Background

NRF-1 regulates mediators of neuronal activity and energy generation.

Results

NRF-1 transcriptionally regulates Na(+)/K(+)-ATPase subunits α1 and β1.

Conclusion

NRF-1 functionally regulates mediators of energy consumption in neurons.

Significance

NRF-1 mediates the tight coupling of neuronal activity, energy generation, and energy consumption at the molecular level. Energy generation and energy consumption are tightly coupled to neuronal activity at the cellular level. Na(+)/K(+)-ATPase, a major energy-consuming enzyme, is well expressed in neurons rich in cytochrome c oxidase, an important enzyme of the energy-generating machinery, and glutamatergic receptors that are mediators of neuronal activity. The present study sought to test our hypothesis th

SUBMITTER: Johar K 

PROVIDER: S-EPMC3504753 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature