Glutamine-mediated dual regulation of heat shock transcription factor-1 activation and expression.

ABSTRACT:

Background

Regulation of transcriptional activity of heat shock factor-1 (HSF1) is widely thought to be the main point of control for heat shock protein (Hsp) expression.

Results

Glutamine increases Hsf1 gene transcription in a C/EBPβ-dependent manner and up-regulates HSF1 activity.

Conclusion

Glutamine is an activator for both HSF1 expression and transactivation.

Significance

Glutamine-induced HSF1 expression provides a novel mechanistic frame for HSF1-Hsp axis regulation. Heat shock transcription factor-1 (HSF1) is the master regulator for cytoprotective heat shock protein (Hsp) expression. It is widely thought that HSF1 expression is non-inducible, and thus the key control point of Hsp expression is regulation of the transactivation activity of HSF1. How HSF

SUBMITTER: Xue H 

PROVIDER: S-EPMC3504755 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature