Sertoli cell-specific expression of metastasis-associated protein 2 (MTA2) is required for transcriptional regulation of the follicle-stimulating hormone receptor (FSHR) gene during spermatogenesis.

ABSTRACT:

Background

Desensitization of FSH response by down-regulation of FSHR transcription is critical for FSH action.

Results

Chromatin modifier MTA2 participates in the down-regulation of FSHR transcription.

Conclusion

The FSH/Ar/MTA2 cascade may serve as an indispensable negative feedback mechanism to modulate FSH transduction events in Sertoli cells.

Significance

Our findings provide new insights into mechanisms by which FSH is deregulated in male infertile patients. The effect of follicle-stimulating hormone (FSH) on spermatogenesis is modulated at a fundamental level by controlling the number of competent receptors present at the surface of Sertoli cells (SCs). One underlying mechanism is the down-regulation of the expression levels of the FSH receptor (FSHR) ge

SUBMITTER: Zhang S 

PROVIDER: S-EPMC3504762 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature