Voltage-dependent anion channels (VDACs) recruit Parkin to defective mitochondria to promote mitochondrial autophagy.

ABSTRACT:

Background

Parkin is recruited to defective mitochondria to promote degradation by an autophagy mechanism (mitophagy).

Results

VDACs specifically interact with Parkin on defective mitochondria and are required for efficient targeting of Parkin to mitochondria and subsequent mitophagy.

Conclusion

VDACs recruit Parkin to defective mitochondria.

Significance

A novel mechanistic aspect of Parkin-dependent mitophagy is proposed that may be relevant to Parkinson disease. Mutations in the ubiquitin ligase Parkin and the serine/threonine kinase PINK1 can cause Parkinson disease. Both proteins function in the elimination of defective mitochondria by autophagy. In this process, activation of PINK1 mediates translocation of Parkin from the cytosol to mitochondria by an un

SUBMITTER: Sun Y 

PROVIDER: S-EPMC3504778 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature