The leukocyte chemotactic receptor FPR1 is functionally expressed on human lens epithelial cells.

ABSTRACT:

Background

Lens degeneration in Fpr1(-/-) mice prompted us to search for functional FPR1 expression directly on lens epithelial cells.

Results

FPR1 is functionally expressed on human lens epithelial cells but has atypical properties compared with hematopoietic cell FPR1.

Conclusion

Lens epithelial cell FPR1 may be involved in development and maintenance of the lens.

Significance

This is the first link between non-hematopoietic expression of FPR1 and an ophthalmologic phenotype. Formyl peptide receptor 1 (FPR1) is a G protein-coupled chemoattractant receptor expressed mainly on leukocytes. Surprisingly, aging Fpr1(-/-) mice develop spontaneous lens degeneration without inflammation or infection (J.-L. Gao et al., manuscript in preparation). Therefore, we hypothe

SUBMITTER: Schneider EH 

PROVIDER: S-EPMC3504790 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature