Monitoring of Vibrio harveyi quorum sensing activity in real time during infection of brine shrimp larvae.

ABSTRACT: Quorum sensing, bacterial cell-to-cell communication, has been linked to the virulence of pathogenic bacteria. Indeed, in vitro experiments have shown that many bacterial pathogens regulate the expression of virulence genes by this cell-to-cell communication process. Moreover, signal molecules have been detected in samples retrieved from infected hosts and quorum sensing disruption has been reported to result in reduced virulence in different host-pathogen systems. However, data on in vivo quorum sensing activity of pathogens during infection of a host are currently lacking. We previously reported that quorum sensing regulates the virulence of Vibrio harveyi in a standardised model system with gnotobiotic brine shrimp (Artemia franciscana) larvae. Here, we monitored quorum sensing activity

SUBMITTER: Defoirdt T 

PROVIDER: S-EPMC3504963 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature