Spatiotemporal control of microRNA function using light-activated antagomirs.

ABSTRACT: MicroRNAs (miRNAs) are small non-coding RNAs that act as post-transcriptional gene regulators and have been shown to regulate many biological processes including embryonal development, cell differentiation, apoptosis, and proliferation. Variations in the expression of certain miRNAs have been linked to a wide range of human diseases - especially cancer - and the diversity of miRNA targets suggests that they are involved in various cellular networks. Several tools have been developed to control the function of individual miRNAs and have been applied to study their biogenesis, biological role, and therapeutic potential; however, common methods lack a precise level of control that allows for the study of miRNA function with high spatial and temporal resolution. Light-activated miRNA antagomir

SUBMITTER: Connelly CM 

PROVIDER: S-EPMC3505109 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature