Second Generation Gold Nanobeacons for Robust K-Edge Imaging with Multi-Energy CT.

ABSTRACT: Spectral CT is the newest advancement in CT imaging technology, which enhances traditional CT images with the capability to image and quantify certain elements based on their distinctive K-edge energies. K-edge imaging feature recognizes high accumulations of targeted elements and presents them as colorized voxels against the normal grayscale X-ray background offering promise to overcome the relatively low inherent contrast within soft tissue and distinguish the high attenuation of calcium from contrast enhanced targets. Towards this aim, second generation gold nanobeacons (GNB(2)), which incorporate at least five times more metal than the previous generation was developed. The particles were synthesized as lipid-encapsulated, vascularly constrained (>120 nm) nanoparticle incorporating tin

SUBMITTER: Schirra CO 

PROVIDER: S-EPMC3505111 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature