Marek's disease virus infection induces widespread differential chromatin marks in inbred chicken lines.

ABSTRACT:

Background

Marek's disease (MD) is a neoplastic disease in chickens caused by the MD virus (MDV). Successful vaccine development against MD has resulted in increased virulence of MDV and the understanding of genetic resistance to the disease is, therefore, crucial to long-term control strategies. Also, epigenetic factors are believed to be one of the major determinants of disease response.

Results

Here, we carried out comprehensive analyses of the epigenetic landscape induced by MDV, utilizing genome-wide histone H3 lysine 4 and lysine 27 trimethylation maps from chicken lines with varying resistance to MD. Differential chromatin marks were observed on genes previously implicated in the disease such as MX1 and CTLA-4 and also on genes reported in other cancers including IGF2

SUBMITTER: Mitra A 

PROVIDER: S-EPMC3505159 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature