Quantitative analysis of light-phase restricted feeding reveals metabolic dyssynchrony in mice.

ABSTRACT:

Background

Considerable evidence suggests that the time of day at which calories are consumed markedly impacts body weight gain and adiposity. However, a precise quantification of energy balance parameters during controlled animal studies enforcing time-of-day-restricted feeding is currently lacking in the absence of direct human interaction.

Objective

The purpose of the present study was therefore to quantify the effects of restricted feeding during the light (sleep)-phase in a fully-automated, computer-controlled comprehensive laboratory animal monitoring system (CLAMS) designed to modulate food access in a time-of-day-dependent manner. Energy balance, gene expression (within metabolically relevant tissues), humoral factors and body weight were assessed.

Results

We

SUBMITTER: Bray MS 

PROVIDER: S-EPMC3505273 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature