Network- and attribute-based classifiers can prioritize genes and pathways for autism spectrum disorders and intellectual disability.

ABSTRACT: Autism spectrum disorders (ASD) are a group of related neurodevelopmental disorders with significant combined prevalence (∼1%) and high heritability. Dozens of individually rare genes and loci associated with high-risk for ASD have been identified, which overlap extensively with genes for intellectual disability (ID). However, studies indicate that there may be hundreds of genes that remain to be identified. The advent of inexpensive massively parallel nucleotide sequencing can reveal the genetic underpinnings of heritable complex diseases, including ASD and ID. However, whole exome sequencing (WES) and whole genome sequencing (WGS) provides an embarrassment of riches, where many candidate variants emerge. It has been argued that genetic variation for ASD and ID will cluster in genes invol

SUBMITTER: Kou Y 

PROVIDER: S-EPMC3505691 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature