Behavior in the open field predicts the number of KCl-induced cortical spreading depressions in rats.

ABSTRACT: Anxiety disorders are known to be comorbid with migraine, and cortical spreading depression (CSD) is the most likely cause of the migraine aura. To search for possible correlations between susceptibility to CSD and anxiety we used the open field test in male Sprague-Dawley rats chronically treated with the preventive anti-migraine drugs valproate or riboflavin. Animals avoiding the central area of the open field chamber and those with less exploratory activity (i.e. rearing) were considered more anxious. After 4 weeks of treatment CSDs were elicited by application of 1M KCl over the occipital cortex and the number of CSDs occurring over a 2h period was compared to the previously assessed open field behavior. Higher anxiety-like behavior was significantly correlated with a higher frequency

SUBMITTER: Bogdanov VB 

PROVIDER: S-EPMC3505753 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature