Fatal lactic acidosis in a kidney transplant recipient on combination antiretroviral therapy after initiation of tacrolimus therapy.

ABSTRACT: In general, kidney transplantation is safe and efficacious in patients receiving treatment for HIV. Although multiple drug interactions between antiviral and immunosuppressive treatments exist, few patients experience serious adverse reactions. We report a case of fatal lactic acidosis in a healthy kidney transplant recipient with stable HIV infection who had previously received treatment for and cleared hepatitis C virus infection. Death occurred less than one month following the initiation of tacrolimus therapy. Based on predicted drug interactions, appropriate tacrolimus dosing was calculated prior to its commencement, yet plasma tacrolimus levels were initially unexpectedly high. The patient subsequently developed lactic acidosis and hepatic steatosis, presumably due to mitochondrial t

SUBMITTER: Holmes MV 

PROVIDER: S-EPMC3505952 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature