Analysis of the epigenetic status of telomeres by using ChIP-seq data.

ABSTRACT: The chromatin structure of eukaryotic telomeres plays an essential role in telomere functions. However, their study might be impaired by the presence of interstitial telomeric sequences (ITSs), which have a widespread distribution in different model systems. We have developed a simple approach to study the chromatin structure of Arabidopsis telomeres independently of ITSs by analyzing ChIP-seq data. This approach could be used to study the chromatin structure of telomeres in some other eukaryotes. The analysis of ChIP-seq experiments revealed that Arabidopsis telomeres have higher density of histone H3 than centromeres, which might reflects their short nucleosomal organization. These experiments also revealed that Arabidopsis telomeres have lower levels of heterochromatic marks than centro

SUBMITTER: Vaquero-Sedas MI 

PROVIDER: S-EPMC3505975 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature