Is phototherapy exposure associated with better or worse outcomes in 501- to 1000-g-birth-weight infants?

ABSTRACT:

Aim

 To compare risk-adjusted outcomes at 18- to 22-month-corrected age for extremely low birth weight (ELBW) infants who never received phototherapy (NoPTx) to those who received any phototherapy (PTx) in the NICHD Neonatal Research Network randomized trial of Aggressive vs. Conservative Phototherapy.

Methods

Outcomes at 18 to 22-month-corrected age included death, neurodevelopmental impairment (NDI) and Bayley Scales Mental Developmental Index (MDI). Regression models evaluated the independent association of PTx with adverse outcomes controlling for centre and other potentially confounding variables.

Results

Of 1972 infants, 216 were NoPTx and 1756 were PTx. For the entire 501- to 1000-g-BW cohort, PTx was not independently associated with death or NDI (OR 0.85, 95%

SUBMITTER: Hintz SR 

PROVIDER: S-EPMC3505994 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature