Regulation of microRNA-155 in atherosclerotic inflammatory responses by targeting MAP3K10.

ABSTRACT:

Aims

Accumulating evidence suggest that numerous microRNAs (miRNAs) play important roles in cell proliferation, apoptosis, and differentiation, as well as various diseases that accompany inflammatory responses. Inflammation is known to be a major contributor to atherogenesis. Previous studies provide promising evidence in support of the role of miRNAs in cardiovascular disease. However, mechanistic data on these small molecules in atherosclerosis (AS) are still missing. The present study aims to investigate the potential role of miRNAs in AS.

Methods and results

The miRNA transcriptase was verified by TaqMan real-time polymerase chain reaction assay. Thoracic aorta samples were obtained from Apolipoprotein E knockout mice, and plasma samples were from coronary artery disease

SUBMITTER: Zhu J 

PROVIDER: S-EPMC3506618 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature