The labial gene is required to terminate proliferation of identified neuroblasts in postembryonic development of the Drosophila brain.

ABSTRACT: The developing brain of Drosophila has become a useful model for studying the molecular genetic mechanisms that give rise to the complex neuronal arrays that characterize higher brains in other animals including mammals. Brain development in Drosophila begins during embryogenesis and continues during a subsequent postembryonic phase. During embryogenesis, the Hox gene labial is expressed in the developing tritocerebrum, and labial loss-of-function has been shown to be associated with a loss of regional neuronal identity and severe patterning defects in this part of the brain. However, nothing is known about the expression and function of labial, or any other Hox gene, during the postembryonic phase of brain development, when the majority of the neurons in the adult brain are generated. Her

SUBMITTER: Kuert PA 

PROVIDER: S-EPMC3507175 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature