The COP9 signalosome, cullin 3 and Keap1 supercomplex regulates CHOP stability and adipogenesis.

ABSTRACT: Obesity is one of the most serious health problems of the 21(st) century. It is associated with highly increased risk of type 2 diabetes, high blood pressure, cardiovascular disease as well as several cancers. The expansion of the fat tissue needs the differentiation of preadipocytes to adipocytes, a process called adipogenesis. Dysfunction of adipogenesis is a hallmark of obesity and delineation of underlying mechanisms has high priority for identifying targets for pharmacological intervention. Here we investigate the impact of the COP9 signalosome (CSN), a regulator of cullin-RING ubiquitin ligases (CRLs), and of C/EBP homologous protein (CHOP) on the differentiation of LiSa-2 preadipocytes. CHOP induced by piceatannol or by permanent overexpression in LiSa-2 cells blocks adipocyte diffe

SUBMITTER: Huang X 

PROVIDER: S-EPMC3507224 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature