Ndel1-derived peptides modulate bidirectional transport of injected beads in the squid giant axon.

ABSTRACT: Bidirectional transport is a key issue in cellular biology. It requires coordination between microtubule-associated molecular motors that work in opposing directions. The major retrograde and anterograde motors involved in bidirectional transport are cytoplasmic dynein and conventional kinesin, respectively. It is clear that failures in molecular motor activity bear severe consequences, especially in the nervous system. Neuronal migration may be impaired during brain development, and impaired molecular motor activity in the adult is one of the hallmarks of neurodegenerative diseases leading to neuronal cell death. The mechanisms that regulate or coordinate kinesin and dynein activity to generate bidirectional transport of the same cargo are of utmost importance. We examined how Ndel1, a cy

SUBMITTER: Segal M 

PROVIDER: S-EPMC3507287 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature