Homology modeling a fast tool for drug discovery: current perspectives.

ABSTRACT: Major goal of structural biology involve formation of protein-ligand complexes; in which the protein molecules act energetically in the course of binding. Therefore, perceptive of protein-ligand interaction will be very important for structure based drug design. Lack of knowledge of 3D structures has hindered efforts to understand the binding specificities of ligands with protein. With increasing in modeling software and the growing number of known protein structures, homology modeling is rapidly becoming the method of choice for obtaining 3D coordinates of proteins. Homology modeling is a representation of the similarity of environmental residues at topologically corresponding positions in the reference proteins. In the absence of experimental data, model building on the basis of a known

SUBMITTER: Vyas VK 

PROVIDER: S-EPMC3507339 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature