Ontology highlight
ABSTRACT:
SUBMITTER: Bogunovic D
PROVIDER: S-EPMC3507439 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20120802 6102
ISG15 is an interferon (IFN)-α/β-inducible, ubiquitin-like intracellular protein. Its conjugation to various proteins (ISGylation) contributes to antiviral immunity in mice. Here, we describe human patients with inherited ISG15 deficiency and mycobacterial, but not viral, diseases. The lack of intracellular ISG15 production and protein ISGylation was not associated with cellular susceptibility to any viruses that we tested, consistent with the lack of viral diseases in these patients. By contras ...[more]