Ancestral effect on HOMA-IR levels quantitated in an American population of Mexican origin.

ABSTRACT:

Objective

An elevated insulin resistance index (homeostasis model assessment of insulin resistance [HOMA-IR]) is more commonly seen in the Mexican American population than in European populations. We report quantitative ancestral effects within a Mexican American population, and we correlate ancestral components with HOMA-IR.

Research design and methods

We performed ancestral analysis in 1,551 participants of the Cameron County Hispanic Cohort by genotyping 103 ancestry-informative markers (AIMs). These AIMs allow determination of the percentage (0-100%) ancestry from three major continental populations, i.e., European, African, and Amerindian.

Results

We observed that predominantly Amerindian ancestral components were associated with increased HOMA-IR (β = 0.124, P =

SUBMITTER: Qu HQ 

PROVIDER: S-EPMC3507582 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature