Immune genes are associated with human glioblastoma pathology and patient survival.

ABSTRACT:

Background

Glioblastoma (GBM) is the most common and lethal primary brain tumor in adults. Several recent transcriptomic studies in GBM have identified different signatures involving immune genes associated with GBM pathology, overall survival (OS) or response to treatment.

Methods

In order to clarify the immune signatures found in GBM, we performed a co-expression network analysis that grouped 791 immune-associated genes (IA genes) in large clusters using a combined dataset of 161 GBM specimens from published databases. We next studied IA genes associated with patient survival using 3 different statistical methods. We then developed a 6-IA gene risk predictor which stratified patients into two groups with statistically significantly different survivals. We validated this ri

SUBMITTER: Vauleon E 

PROVIDER: S-EPMC3507656 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature