Sex-related differences in sleep slow wave activity in major depressive disorder: a high-density EEG investigation.

ABSTRACT:

Background

Sleep disturbance plays an important role in major depressive disorder (MDD). Prior investigations have demonstrated that slow wave activity (SWA) during sleep is altered in MDD; however, results have not been consistent across studies, which may be due in part to sex-related differences in SWA and/or limited spatial resolution of spectral analyses. This study sought to characterize SWA in MDD utilizing high-density electroencephalography (hdEEG) to examine the topography of SWA across the cortex in MDD, as well as sex-related variation in SWA topography in the disorder.

Methods

All-night recordings with 256 channel hdEEG were collected in 30 unipolar MDD subjects (19 women) and 30 age and sex-matched control subjects. Spectral analyses of SWA were performed to de

SUBMITTER: Plante DT 

PROVIDER: S-EPMC3507703 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature